orcid.org/0000-0001-5138-2772Appointments
- Fellow, Hematology/Oncology, Columbia University / New York Presbyterian Hospital, 2023-current
- Postdoctoral Clinical Fellow, Columbia University Medical Center, 2023-current
- Resident, Internal Medicine, Brigham and Women's Hospital, 2020-2023
- Clinical Fellow in Medicine, Harvard Medical School, 2020-2023
Education
- MD, Weill Cornell/Rockefeller/Sloan-Kettering MD/PhD Program, 2020
- PhD, Weill Cornell/Rockefeller/Sloan-Kettering MD/PhD Program, 2018
- B.A., Columbia University, 2010
Impact
I use in silico, in vitro and in vivo approaches to ask fundamental questions about cancer biology.
My doctoral work was motivated by trying to understand how self/non-self discrimination occurs in the context of a tumor.
I developed a novel approach to link MHC-I neoantigen expression to cellular barcodes called “PresentER” (Gejman eLife 2018; Gejman, Ca. Imm. Res. 2020).
“PresentER” allows the creation of libraries of tens of thousands of precisely defined neoantigens to study TCR-reactivity and immunogenicity.
Using PresentER libraries, we discovered that clonally expressed neoantigens could elicit strong immune responses in immunocompetent mice that eliminated tumors, while neoantigens with low clonality or in competition with other neoantigens could not.
This may explain the clinically important inverse relationship between degree of intratumoral heterogeneity and response to immunotherapy in patients with cancer.
We have also used this system to study the target-specificity of T cell receptor-based therapeutics and unexpectedly revealed extensive off-targets for some therapeutic agent classes.
The tools I developed are now being used by dozens of laboratories.
All PresentER vectors are available on AddGene.
Selected Publications
- Martin G.Klatt, Zita E.H.Aretz, Michael Curcio, Ron S. Gejman, Heather F. Jones, David A.Scheinberg. "An input-controlled model system for identification of MHC bound peptides enabling laboratory comparisons of immunopeptidome experiments." Journal of Proteomics 2020. DOI: 10.1016/j.jprot.2020.103921 [Link]
- Ron S Gejman, Heather F Jones, Martin G Klatt, Aaron Y Chang, Claire Y Oh, Smita S. Chandran, Tatyana Korontsvit, Viktoriya Zakahleva, Tao Dao, Christopher A. Klebanoff and David A Scheinberg "Identification of the targets of T cell receptor therapeutic agents and cells by use of a high throughput genetic platform." Cancer Immunology Research 2020. DOI: 10.1158/2326-6066.CIR-19-0745 [Link]
- Ron S. Gejman*, Aaron Y. Chang*, Heather F. Jones, Krysta DiKun, A. Ari Hakimi, Andrea Schietinger, David A. Scheinberg. "Rejection of immunogenic tumor clones is limited by clonal fraction." eLife 2018. DOI: 10.7554/eLife.41090 [Link] [eLife Insight]
- Aaron Y. Chang, Tao Dao, Ron S. Gejman, Casey A. Jarvis, Andrew Scott, Leonid Dubrovsky, Melissa D. Mathias, Tatyana Korontsvit, Victoriya Zakhaleva, Michael Curcio, Ronald C. Hendrickson, Cheng Liu, and David A. Scheinberg. "A therapeutic T cell receptor mimic antibody targets tumor-associated PRAME peptide/HLA-I antigens." JCI. DOI: 10.1172/JCI92335 [Link]
- Yasin Şenbabaoğlu*, Ron S. Gejman*, Andrew G. Winer, Ming Liu, Eliezer M. Van Allen, Guillermo de Velasco, Diana Miao, Irina Ostrovnaya, Esther Drill, Augustin Luna, Nils Weinhold, William Lee, Brandon J. Manley, Danny N. Khalil, Samuel D. Kaffenberger, Yingbei Chen, Ludmila Danilova, Martin H. Voss, Jonathan A. Coleman, Paul Russo, Victor E. Reuter, Timothy A. Chan, Emily H. Cheng, David A. Scheinberg, Ming O. Li, Toni K. Choueiri, James J. Hsieh, Chris Sander and A. Ari Hakimi. "Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures." Genome Biology 2016. DOI: 10.1186/s13059-016-1092-z [Link]
- Elliott J Brea, Claire Y Oh, Eusebio Manchado, Sadna Budhu, Ron S Gejman, George Mo, Patrizia Mondello, James E Han, Casey A Jarvis, David Ulmert, Qing Xiang, Aaron Y Chang, Ralph J Garippa, Taha Merghoub, Jedd D Wolchok, Neal Rosen, Scott W. Lowe and David A Scheinberg. "Kinase regulation of Human MHC Class I Molecule Expression on Cancer Cells.". Cancer Immunol Res 2016. DOI: 10.1158/2326-6066.CIR-16-0177 [Link].
Reviews
- Aaron Y Chang, Ron S Gejman, Elliott J Brea, Claire Y Oh, Melissa Mathias, Dmitry Pankov, Emily Casey, Tao Dao & David A Scheinberg "Opportunities and challenges for TCR mimic antibodies in cancer therapy." Expert Opinion on Biological Therapy 2016. [Link]
- Leonid Dubrovsky, Tao Dao, Ron S Gejman, Elliott Brea, Aaron Chang, Claire Oh, Emily Casey, Dmitry Pankov & David A. Scheinberg. "T cell receptor mimic antibodies for cancer therapy." Oncoimmunology 2015. [Link]
Invited Talks
- The Ability of T Cell Antigens to Cause Tumor Cell Rejection Is Dependent on Tumor Cell Subclone Frequency. Keystone Precision Medicine in Cancer. Stockholm, Sweden. 2018.
- Identification of Cross-reactive Targets of TCR-Based Therapeutic Agents Within the Human Proteome. Vincent du Vigneaud Memorial Research Symposium. New York, NY. 2018.
Abstracts
- Ron S. Gejman, Aaron Chang, Martin Miller, Tanya Korontsvit, Tao Dao and David A. Scheinberg. "Identification of Cross-reactive Targets of TCR-Based Therapeutic Agents Within the Human Proteome." Poster. American Society of Hematology. Atlanta, GA. 2017.
- Ron S. Gejman, Tanya Korontsvit, Tao Dao and David A. Scheinberg. "A high-throughput, cell-based method for screening T cell receptor mimic antibodies against major histocompatibility complex ligands." Poster. Frontiers in Immunotherapy, New York Academy of Sciences. NYC. 2017.
- Ron S. Gejman and David A. Scheinberg. "A high-throughput, cell-based method for screening T cell receptor mimic antibodies against major histocompatibility complex ligands." Poster. Vincent du Vigneaud Memorial Research Symposium. NYC. 2016.
- Ron S. Gejman,Yasin Şenbabaoğlu*, Andrew G. Winer*, Ming Liu, Augustin Luna, Irina Ostrovnaya, Nils Weinhold, William Lee, Samuel D. Kaffenberger, Ying Bei Chen, Martin H. Voss, Paul Russo, Jonathan A. Coleman, Victor E. Reuter, Timothy A. Chan, Emily H. Cheng, David A. Scheinberg, Ming O. Li, James J. Hsieh, Chris Sander, A. Ari Hakimi. "The Landscape Of T Cell Infiltration In Human Cancer And Its Association With Antigen Presenting Gene Expression." Vincent du Vigneaud Memorial Research Symposium 2015 and WCMC Pharmacology Retreat 2015.
- R. S. Gejman, N. Weinhold, C. Sander, D. A. Scheinberg. "Mining Next Generation Sequencing Data for Evidence of Cancer Immunoediting." WCMC Pharmacology Retreat. 2014.
- R. S. Gejman, L. Chasin. "Silencing Pseudoexons: A Cis-Element Story." SURF Colloquium. Columbia University, NYC. 2008
- R. S. Gejman, J. S. Otto, J. Duan, J. OConnell and M. Martinez. "LSMatchMaker: An Integrated Environment for Association Analysis." International Genetic Epidemiology Society Conference. Park City, Utah. 2005
- J. S. Otto, R. S. Gejman, J. Duan, J. OConnell and M. Martinez. "LSMatchMaker: An Integrated Environment for Association Analysis." World Congress on Psychiatric Genetics XIII. Boston, Massachusetts. 2005.
Awards and Recognition
- Best Talk, Vincent du Vigneaud Memorial Research Symposium, WMC, 2018
- Keystone Symposia Future of Science Fund scholarship, 2018
- Abstract Achievement Award, American Society of Hematology, 2017
- Best Talk (5th year student), WMC Molecular Pharmacology Retreat, 2017
- Best Poster (2nd year and above), Vincent du Vigneaud Memorial Research Symposium, WMC, 2016
- Ruth L. Kirschstein National Research Service Award (NRSA) F30 Award, NIH/NCI, 2015
- Best Poster (2nd year and above), Pharmacology Retreat, WCMC, 2015
- Adam Leroy Jones Prize in Logic. Columbia University, 2010
- Carl B. Boyer Memorial Prize in the History of Science. Columbia University, 2010
- Summer Undergraduate Research Fellowship (SURF). Columbia University, 2007
Teaching/Mentorship
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Big Sib,
Gateways to the Laboratory Summer Program,
Summer 2015, Summer 2016
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Journal Club TA for Weill Cornell Medical Students
Fall 2013
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Teaching Assistant: C2005 Intro Bio, Columbia University
Fall 2008, Fall 2009
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Teaching Assistant: W3031 Genetics, Columbia University
Spring 2009
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Independent Tutoring: Computer Science and Biology
Summer 2007 – 2011